Sequential noise-induced escapes for oscillatory network dynamics

It is well known that the addition of noise in a multistable system can induce random transitions between stable states. The rate of transition can be characterised in terms of the noise-free system's dynamics and the added noise: for potential systems in the presence of asymptotically low noise the well-known Kramers' escape time gives an expression for the mean escape time. This paper examines some general properties and examples of transitions between local steady and oscillatory attractors within networks: the transition rates at each node may be affected by the dynamics at other nodes. We use first passage time theory to explain some properties of scalings noted in the literature for an idealised model of initiation of epileptic seizures in small systems of coupled bistable systems with both steady and oscillatory attractors. We focus on the case of sequential escapes where a steady attractor is only marginally stable but all nodes start in this state. As the nodes escape to the oscillatory regime, we assume that the transitions back are very infrequent in comparison. We quantify and characterise the resulting sequences of noise-induced escapes. For weak enough coupling we show that a master equation approach gives a good quantitative understanding of sequential escapes, but for strong coupling this description breaks down

Sequential escapes: onset of slow domino regime via a saddle connection

We explore sequential escape behaviour of coupled bistable systems under the influence of stochastic perturbations. We consider transient escapes from a marginally stable "quiescent" equilibrium to a more stable "active" equilibrium. The presence of coupling introduces dependence between the escape processes: for diffusive coupling there is a strongly coupled limit (fast domino regime) where the escapes are strongly synchronised while for intermediate coupling (slow domino regime) without partially escaped stable states, there is still a delayed effect. These regimes can be associated with bifurcations of equilibria in the low-noise limit. In this paper we consider a localized form of non-diffusive (i.e pulse-like) coupling and find similar changes in the distribution of escape times with coupling strength. However we find transition to a slow domino regime that is not associated with any bifurcations of equilibria. We show that this transition can be understood as a codimension-one saddle connection bifurcation for the low-noise limit. At transition, the most likely escape path from one attractor hits the escape saddle from the basin of another partially escaped attractor. After this bifurcation we find increasing coefficient of variation of the subsequent escape times

Fast and slow domino regimes in transient network dynamics

It is well known that the addition of noise to a multistable dynamical system can induce random transitions from one stable state to another. For low noise, the times between transitions have an exponential tail and Kramers' formula gives an expression for the mean escape time in the asymptotic limit. If a number of multistable systems are coupled into a network structure, a transition at one site may change the transition properties at other sites. We study the case of escape from a "quiescent" attractor to an "active" attractor in which transitions back can be ignored. There are qualitatively different regimes of transition, depending on coupling strength. For small coupling strengths the transition rates are simply modified but the transitions remain stochastic. For large coupling strengths transitions happen approximately in synchrony - we call this a "fast domino" regime. There is also an intermediate coupling regime some transitions happen inexorably but with a delay that may be arbitrarily long - we call this a "slow domino" regime. We characterise these regimes in the low noise limit in terms of bifurcations of the potential landscape of a coupled system. We demonstrate the effect of the coupling on the distribution of timings and (in general) the sequences of escapes of the system.Comment: 3 figure

Informal payments - definitions and concepts

Informal payments became an interesting issue in the context of healthcare reforms and a very widespreadphenomenon in the healthcare sector that has been observed in many transition countries of Central and Eastern Europe, Asia and Africa. Some studies have been conducted to clearly identify informal payments to overcome this complex problem with many „faces`. The latter includes a variety of names to denote the phenomenon: gratuities, gratitude payments, under-the-counter payments, unofficial payments and etc. The concepts mentioned in the current article such as illegality, informality, and corruption have a negative impact inthe understanding of the informal payment. The main strategies of the world literature to deal with this phenomenon are summarized

Innovative and intelligent solutions for recycling of household waste in Bulgaria

Waste from industrial and other human activities, as well as household waste is a major source of environmental pollution. If it is controlled and managed in a adequate and intelligent way, the waste can be a valuable source of raw materials, especially considering that many of them are becoming more and more scarce. Many countries still manage their waste by landfills, although they are not sustainable in the long run. Landfill sites are potential pollutants of soil, water and air. The uncontrolled waste disposal can cause the release of chemicals that pose a danger to the human life and health. Among other things, the valuable materials in waste are lost. It is impossible to stop waste generation and the only alternative is their reuse through recycling and innovative utilization. Good waste management can greatly contribute to economic growth and work places creation. It saves valuable resources, helps to avoid expensive cleaning activities, as well as to prevent health and environmental problems. This study aims to analyze the situation of waste treatment in Bulgaria and to search for innovative intelligent solutions, based on international experience and best practices.

Control of Ca2+ influx and calmodulin activation by SK-channels in dendritic spines (dataset)

A 3-dimensional model of Ca2+ and calmodulin dynamics within an idealised, but biophysically-plausible, dendritic spine, demonstrates that SK-channels regulate calmodulin activation specifically during neurone firing patterns associated with induction of spike timing-dependent plasticity.The journal article associated with this dataset is available at: http://hdl.handle.net/10871/21745.The key trigger for Hebbian synaptic plasticity is influx of Ca2+ into postsynaptic dendritic spines. The magnitude of [Ca2+] increase caused by NMDA-receptor (NMDAR) and voltage-gated Ca2+ -channel (VGCC) activation is thought to determine both the amplitude and direction of synaptic plasticity by differential activation of Ca2+ -sensitive enzymes such as calmodulin. Ca2+ influx is negatively regulated by Ca2+ -activated K+ channels (SK-channels) which are in turn inhibited by neuromodulators such as acetylcholine. However, the precise mechanisms by which SK-channels control the induction of synaptic plasticity remain unclear. Using a 3-dimensional model of Ca2+ and calmodulin dynamics within an idealised, but biophysically-plausible, dendritic spine, we show that SK-channels regulate calmodulin activation specifically during neuron-firing patterns associated with induction of spike timing-dependent plasticity. SK-channel activation and the subsequent reduction in Ca2+ influx through NMDARs and L-type VGCCs results in an order of magnitude decrease in calmodulin (CaM) activation, providing a mechanism for the effective gating of synaptic plasticity induction. This provides a common mechanism for the regulation of synaptic plasticity by neuromodulators

Dynamical systems analysis of spike-adding mechanisms in transient bursts

The electronic version of this article is the complete one and can be found online at: doi:10.1186/2190-8567-2-7Open Access ArticleTransient bursting behaviour of excitable cells, such as neurons, is a common feature observed experimentally, but theoretically, it is not well understood. We analyse a five-dimensional simplified model of after-depolarisation that exhibits transient bursting behaviour when perturbed with a short current injection. Using one-parameter continuation of the perturbed orbit segment formulated as a well-posed boundary value problem, we show that the spike-adding mechanism is a canard-like transition that has a different character from known mechanisms for periodic burst solutions. The biophysical basis of the model gives a natural time-scale separation, which allows us to explain the spike-adding mechanism using geometric singular perturbation theory, but it does not involve actual bifurcations as for periodic bursts. We show that unstable sheets of the critical manifold, formed by saddle equilibria of the system that only exist in a singular limit, are responsible for the spike-adding transition; the transition is organised by the slow flow on the critical manifold near folds of this manifold. Our analysis shows that the orbit segment during the spike-adding transition includes a fast transition between two unstable sheets of the slow manifold that are of saddle type. We also discuss a different parameter regime where the presence of additional saddle equilibria of the full system alters the spike-adding mechanism.Engineering and Physical Sciences Research Council (EPSRC

Bacterial secretion and the role of diffusive and subdiffusive first passage processes

Open Access ArticleBy funneling protein effectors through needle complexes located on the cellular membrane, bacteria are able to infect host cells during type III secretion events. The spatio-temporal mechanisms through which these events occur are however not fully understood, due in part to the inherent challenges in tracking single molecules moving within an intracellular medium. As a result, theoretical predictions of secretion times are still lacking. Here we provide a model that quantifies, depending on the transport characteristics within bacterial cytoplasm, the amount of time for a protein effector to reach either of the available needle complexes. Using parameters from Shigella flexneri we are able to test the role that translocators might have to activate the needle complexes and offer semi-quantitative explanations of recent experimental observations.Engineering and Physical Sciences Research Council (EPSRC)Medical Research Council (MRC

Modeling Joint Improvisation between Human and Virtual Players in the Mirror Game

Joint improvisation is observed to emerge spontaneously among humans performing joint action tasks, and has been associated with high levels of movement synchrony and enhanced sense of social bonding. Exploring the underlying cognitive and neural mechanisms behind the emergence of joint improvisation is an open research challenge. This paper investigates the emergence of jointly improvised movements between two participants in the mirror game, a paradigmatic joint task example. A theoretical model based on observations and analysis of experimental data is proposed to capture the main features of their interaction. A set of experiments is carried out to test and validate the model ability to reproduce the experimental observations. Then, the model is used to drive a computer avatar able to improvise joint motion with a human participant in real time. Finally, a convergence analysis of the proposed model is carried out to confirm its ability to reproduce the emergence of joint movement between the participants